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Cardiac Markers – CK-MB

Used in the diagnosis and treatment of AMI.

Creatine kinase (CK) is a dimer composed of M and B subunits. There are three isozymes in the cytoplasm: CK-MM, CK-MB and CK-BB. Creatine kinase isozyme (CK-MB) is one of the three isomers of creatine kinase (CK), with a molecular weight of 84KD. Creatine kinase is a major enzyme of muscle metabolism that facilitates the reversible reaction of creatine phosphorylation by adenosine triphosphate (ATP). Creatine kinase is a major enzyme in muscle metabolism, which contributes to the reversible reaction of creatinine phosphorylation produced by adenosine triphosphate (ATP). When myocardial tissue is seriously damaged, creatine kinase isozyme (CK-MB) is released into the blood, and creatine kinase isozyme (CK-MB) in serum becomes an important criterion for the diagnosis of acute myocardial infarction . Serum creatine kinase isoenzyme (CK-MB) is one of the important indexes widely used in clinical diagnosis of heart disease, especially in the auxiliary diagnosis of acute myocardial infarction (AMI). The combined detection with troponin I (cTnI) and myoglobin (myo) is of great value in the early diagnosis of acute myocardial infarction (AMI) .


Product Detail

Product Tags

Major Components

Microparticles(M): 0.13mg/ml Microparticles coupled with anti MB isoenzyme of creatine kinase antibody
Reagent 1(R1): 0.1M Tris buffer
Reagent 2(R2): 0.5μg/ml Alkaline phosphatase labeled anti MB isoenzyme of creatine kinase antibody
Cleaning solution: 0.05% surfactant、0.9% Sodium chloride buffer
Substrate: AMPPD in AMP buffer
Calibrator(optional): MB isoenzyme of creatine kinase antigen
Control materials(optional): MB isoenzyme of creatine kinase antigen

 

Note:
1.Components are not interchangeable between batches of reagent strips;
2.See the calibrator bottle label for calibrator concentration;
3.See the control bottle label for the concentration range of controls

Storage And Validity

1.Storage: 2℃~8℃, avoid direct sunlight.
2.Validity: unopened products are valid for 12 months under specified conditions.
3.Calibrators and controls after dissolved can be stored for 14 days in 2℃~8℃ dark environment.

Applicable Instrumen

Automated CLIA System of  Illumaxbio (lumiflx16、lumiflx16s、lumilite8、lumilite8s).


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